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KMID : 1005220070220040199
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Journal of Embryo Transfer
2007 Volume.22 No. 4 p.199 ~ p.208
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Unexpected Estrogenicity of Endocrine Disruptors may Evoke a Failure of Pregnancy Derived from Uterine Function: Overview of Their Possible Mechanism(s) through Steroid Receptors
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Dang V.H.
Nguyen T.H.
Choi K.C.
Jeung E.B.
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Abstract
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Although many studies have focused on the biological and toxicological effects of phenol products, in particular, in reproductive tracts, the data about their effects in this estrogenic responsive tissue are much less clear. In addition, the in vitro and in vivo data concerning ED-adverse impacts in other endocrine organs, i.e. pituitary gland, are not understood well either. Thus, a further study is needed for providing a new insight into possible impacts of estrogenic EDs including phenol products in humans and wildlife. A combination of in vitro and in vivo system for examining EDs may bring better understanding into the regulatory mechanisms underlying EDs-induced events. In addition, this information may support for developing optimal screening methods of estrogenic EDs, in particular, phenol products.
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KEYWORD
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endocrine disruptors, estrogenicity, cDNA microarray, uterotrophic
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